Diagnosit ® BVBLUE ® / Bacterial Vaginosis / Sialidases, Pregnancy, and BV
Diagnosit ® BVBLUE ® / Bacterial Vaginosis / Sialidases, Pregnancy, and BV

Sialidases, Pregnancy, and BV

Sialidases (EC are of considerable importance in women’s health in that they have been shown to act in a way that enhances the attachment of bacteria to mucosal tissue (i.e., thin membrane that lines the urogenital system in this case) thereby allowing the invasion of the bacteria and destruction of the mucosal tissue. This is done through the breakage of sialic acid residues from sialylglycoconjugates.

In fact, sialidases have been identified as a virulence factor in the infection of many bacteria including Gardnerella vaginalis, Bacteroides spp., Prevotella spp., and Mobilucus spp., bacterial pathogens associated with Bacterial Vaginosis (BV).

Recent advancements in clinical medicine have demonstrated a clear association between the presence of …

Elevated vaginal fluid sialidases and an increased risk of pre-term birth:


Fakultesi, T. et al. 2014. Assessment of maternal serum sialic acid levels in preterm versus term labor: a prospective-controlled clinical study. Bioportfolio. March 12th.


Lewis, W. G. et al. 2013. Degradation, Foraging, and Depletion of Mucus Sialoglycans by the Vagina-adapted Actinobacterium Gardnerella vaginalis* J. Biol Chem. 288:12067.

Marconi, C. et.al. 2013. Do Atopobium vaginae, Megasphaera sp. and Leptotrichia sp. change the local innate immune response and sialidase activity in bacterial vaginosis? Sex. Transm. Infect. 89: 167.

2012 and Prior Years

Cauci, S. et al. 2011. High sialidase levels increase preterm birth risk among women who are bacterial vaginosis–positive in early gestation. Am. J. Obstet. Gynecol. 204:142e.

Krauss-Silva, L. et al. 2010. Randomized controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with intrauterine infection: study protocol. Reproductive Health 7:14.

Cauci, S. et al. 2003. Determination of Immunoglobin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid. Implications for adverse pregnancy outcomes. J. Clin. Microbiol. 41:435.

Cauci, s. et al. 2002. Correlation of local interleukin-8 with Immunoglobin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. J. Infect. Dis. 185:1614.

Smayevsky, J. et al. 2001. Vaginal microflora associated with bacterial vaginosis in nonpregnant women: reliability of sialidase detection. Infect. Dis. Obstet. Gynecol. 9:17.

Wiggins, R. et al. 2001. Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract. Sex. Transm. Infect. 77:402.

Cauci, S. et al. 1998. Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis. Am. J. Obstet. Gynecol. 178:511.

McGregor, J.A. et al. 1994. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. Am. J. Obstet. Gynecol. 170:1048.

Elevated Sialidase Activity, Bacterial Vaginosis, and Clinical Performance of Diagnosit® BVBLUE®:


Gag, ZG.F.M. et al. 2014. Evaluation of different diagnostic methods of bacterial vaginosis. J. Dental Med. Sci. 13: 15.

2014. The Point of Care Test Health Essay. UKessays.


Marconi, C. et al. 2013. Sialidase activity in aerobic vaginitis is equal to levels during bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol. 167:205.

2012 and Prior Years

Kampan, N.C. et al. 2011. Evaluation of BVBLUE® Test Kit for the diagnosis of bacterial vaginosis. Sex. Reproduct. Healthcare 2: 1. http://www.sciencedirect.com/science/article/pii/S1877575610000790

Shujatullah, F. et al. 2010. An evaluation of OSOM BVBLUE® test in the diagnosis of bacterial vaginosis. Asian J. Trop. Med. 3: 574. http://www.sciencedirect.com/science/article/pii/S1995764510601393

Akhter, S. et al. 2010. Rapid detection of Bacterial Vaginosis (BV) by BVBLUE® test. Bangladesh J. Med. Microbiol. 4: 24. http://www.banglajol.info/index.php/BJMM/article/view/8465

Anukam, K. et al. 2006. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, plaebo controlled trial. Microbes and infection 8: 1450e.

Sumeksri, P. et al. 2005. BVBLUE® test for diagnosis of bacterial vaginosis in pregnant women attending antenatal care at Phramongkutklao Hospital. J. Med. Assoc. Thailand 88:S7. http://www.scopus.com/record/display.url?eid=2-s2.0-33749048743&origin=inward&txGid=2F95611692479A404845D3BFCF16DAA3.aqHV0EoE4xlIF3hgVWgA%3a2

Bradshaw, C.S. et al. 2005. Evaluation of point-of-care test, Diagnosit® BVBLUE®, and clinical and laboratory criteria for diagnosis of bacterial vaginosis. J. Clin. Microbiol. 43:1304.

Myziuk, L. et al. 2003. Diagnosit® BVBLUE® test for diagnosis of bacterial vaginosis. J. Clin. Microbiol. 41:1925.

Briselden, A. et al. 1992. Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora. J. Clin. Microbiol. 30:663.

Moncla, B.J. et al. 1990. Sialidase (neuraminidase) activity among gram-negative anaerobic and capnophilic bacteria. J. Clin. Microbiol. 28:422.